The evolution of high-order genome architectures revealed from 1000 species

Genomes are not mere linear strings of DNA; they are intricate, dynamic structures that fold and interact within the nucleus, profoundly influencing gene activity. This study delves into the 3D spatial organization of chromosomes across 1000 species, revealing high diversity in genome architectures throughout the Tree of Life. We uncover key principles governing this organization, such as global architectures and the formation of distinct compartments. By analyzing how these features evolve, we gain crucial insights into their impact on gene regulation, cellular function, and the emergence of new traits and species.