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Joshua Blodgett, assistant professor of biology in Arts & Sciences at Washington University in St. Louis, received a five-year, $900,500 CAREER grant from the National Science Foundation (NSF) to support his research related to actinomycete bacteria. This bacteria produces a majority of current antibiotics and may harbor other useful small molecules that could be revealed by activating silent genes.

A common chemical used to kill bacteria is making them more capable of surviving antibiotics. According to new research from Washington University, triclosan has a protective effect on strains of E. coli and methicillin-resistant Staphylococcus aureus, or MRSA. The chemical — which is added to hundreds of consumer products — also interferes with the antibiotic treatment of urinary-tract infections in mice. The U.S. Food and Drug Administration banned triclosan and 18 other antibacterial chemicals from consumer soaps in 2016, on the grounds that they are “not generally recognized as safe and effective.”

“The scientific evidence presently available indicates that installing perennial standard time — or ‘wintertime’ — is the best and safest option for public health,” said Erik Herzog, professor of biology in Arts & Sciences at Washington University in St Louis and president of the Society for Research on Biological Rhythms.

Arpita Bose, assistant professor of biology, received a $7,500 award from the U.S. Army to support research on understanding how microbes interact with charged surfaces.

Joshua Blodgett, assistant professor of biology, was awarded a $900,500 CAREER grant from the National Science Foundation to investigate leveraging polycyclic tetramate macrolactam biosunthesis as a model for understanding actinobacterial metabolic silencing.

Grocery store aisles are stocked with products that promise to kill bacteria. People snap up those items to protect themselves from the germs that make them sick. However, new research from Washington University in St. Louis finds that a chemical that is supposed to kill bacteria is actually making them stronger and more capable of surviving antibiotic treatment. The study, available online Feb. 19 in the journal Antimicrobial Agents & Chemotherapy, suggests that triclosan exposure may inadvertently drive bacteria into a state in which they are able to tolerate normally lethal concentrations of antibiotics — including those antibiotics that are commonly used to treat urinary tract infections (UTIs).

Until this point, most bee researchers thought bees recognize and respond to a scent that is the homogenized scent of all of the members of their own colony. That’s how it works for some ants and other insects, at least. But new work from the laboratory of Yehuda Ben-Shahar, associate professor of biology in Arts & Sciences, shows that nestmate recognition instead depends on an innate developmental process that is associated with age-dependent division of labor. The work was completed in collaboration with researchers from the lab of Joel Levine at the University of Toronto.

The American Academy of Microbiology has named three Washington University in St. Louis faculty members as fellows: Gautam Dantas, professor of pathology and immunology at the School of Medicine, and Robert Kranz and Petra Levin, professors of biology in Arts & Sciences. The faculty are among 109 fellows elected this year to the academy, which recognizes scientific achievement and original contributions that have advanced microbiology.

“There’s no reasonable definition as to what an organism is – at the same time it is the most important unit of life. Of course much has been written on the subject, for instance that all parts of an organism must be related, that they are surrounded by a skin, that organisms emerge from a cell. But none of these definitions seem to work universally because most researchers have only examined a small snippet of the world of living beings.” -Joan Strassmann

Roy Curtiss III began crossing tomatoes at age 10, then chickens at age 12, and eventually bacterial viruses at age 21. He switched to the study of genetics of bacterial pathogens, starting in Alabama and continuing at Wash U. Roy studied leprosy and salmonella, learning the biochemical and genetic basis, why they were successful, and how he could use this info to develop better vaccines and diagnostics. Possessing a strong ethical streak, he wanted to use what he learned to benefit society. He entered the world of disease prevention and vaccine development, and started a company in 1992 called Megan Health which developed salmonella vaccines for poultry and swine.

Heather Barton grew up in Meadville, a tiny town in western Pennsylvania. She completed her undergrad work at Grove City College near her hometown. Her family, including her parents and four sisters, lived a quiet country lifestyle. She spent many hours as a child playing outside in the dirt, in streams and in the woods. Nature was a big part of her life from a very young age and her desire to figure out how things work in nature was a driving force behind her interest in biology.

Eye-catching and nutritious, purple rice has been a part of religious and cultural ceremonies across Asia for generations. New research from Washington University in St. Louis uncovers the ways that traditional farming practices have preserved the genetic diversity of Thai purple rice.

Researchers are creating their own podcasts on topics ranging from exoplanets to graduate-student finances.

The 2019 St. Louis Area Brain Bee is set for 1 to 5 p.m. Saturday, February 16, at Washington University’s Danforth Campus. Herzog works with undergraduate and graduate students to formulate the Brain Bee questions. He also taps into his archives, recycling questions from prior years. And for the first time, the Society for Neuroscience, which sponsors the national and international Brain Bee competitions, will provide 100 standardized questions which Herzog is free to use. The competition, open to high school and homeschool students in grades 9-12, starts with a written exam. The top 10 finishers then move on to an oral round, which resembles a spelling bee where students take turns answering questions about the brain and nervous system.

“As an instructor, I try to teach how the topic has relevance from different approaches in biology,” said Erik Herzog, Professor of Biology at Washington University in St. Louis. Herzog teaches undergraduate biology courses at the university. His lab uses a variety of techniques to study the cellular and molecular basis of circadian rhythms, biological clocks that drive near 24-hour rhythms in living beings including animals and plants.

In a new publication in the journal Nature Plants, researchers [led by Richard Vierstra] in Arts & Sciences describe the effects of autophagy on metabolism in maize, commonly known as corn, an important crop that is sensitive to nitrogen deprivation.

How does evolution select the fittest “individuals” when they are ecosystems made up of hosts and their microbiomes? Joan Strassmann and other biologists debate the need to revise theories.

The American Association for the Advancement of Science has bestowed upon 416 of its members the lifetime honor of being an elected Fellow in recognition of their extraordinary achievements in advancing science. . .This year’s Fellows, who represent a broad swath of scientific disciplines, were selected for diverse accomplishments that include pioneering research, leadership within their field, teaching and mentoring, fostering collaborations and advancing public understanding of science.

Researchers from Washington University in St. Louis have mapped the regions of the brain in mormyrid fish in extremely high detail. In a new study published in the Nov. 15 issue of Current Biology, they report that the part of the brain called the cerebellum is bigger in members of this fish family compared to related fish — and this may be associated with their use of weak electric discharges to locate prey and to communicate with one another.

How does sensory processing lend itself to life as we know it? If our experiences materialize due to sensory transduction, do these processes inspire our entire perspective? These questions sparked Mary Lambo’s interest in neuroscience and eventually motivated her research in neural plasticity and sensory processing. As new teaching faculty at Wash U, Mary now guides students through fundamental neuroscience concepts and challenges them to discover their own motivating questions.

How predictable is evolution? The answer long has been debated by biologists grappling with the extent to which history affects the repeatability of evolution. A review published in the Nov. 9 issue of Science explores the complexity of evolution’s predictability in extraordinary detail. In it, researchers from Kenyon College, Michigan State University and Washington University in St. Louis closely examine evidence from a number of empirical studies of evolutionary repeatability and contingency in an effort to fully interrogate ideas about contingency’s role in evolution.

Most of the country switched their clocks back an hour over the weekend, ending daylight saving time. And even though one hour might not sound like a lot, it has a noticeable impact. "In the long term, this one hour cumulatively can really have effects on our health," says Erik Herzog, professor of biology and neuroscience at Washington University in St. Louis.

Richard D. Vierstra, the George and Charmaine Mallinckrodt Professor in the Department of Biology in Arts & Sciences, received a $304,000 grant from the National Institutes of Health (NIH) for a project titled “Phytochromes: Structural perspectives on photoactivation and signaling.” Vierstra was also granted $49,000 from the NIH to study autophagic clearance of inactive proteasomes and ribosomes as models for protein quality control.

David L. Kirk, professor emeritus of biology in Arts & Sciences at Washington University in St. Louis, died Thursday, Nov. 1, 2018, at Dougherty Ferry Assisted Living in St. Louis after a long illness. He was 84. Kirk, who was an active and passionate member of the university community for nearly 50 years, spent a lifetime teaching developmental biology and researching the evolutionary origins of multicellular organisms. He was internationally known for his research on the spherical green alga known as Volvox carteri.

Himadri Pakrasi, the Myron and Sonya Glassberg/Albert and Blanche Greensfelder Distinguished University Professor in the Department of Biology, received a $1.5 million award from the U.S. Department of Energy to develop Anabaena 33047 — a photosynthetic, fast-growing, nitrogen-fixing cyanobacteria — as a versatile production platform that can be used by the bioenergy research community.

Next Generation Leaders are selected each year through a competitive process that includes applications from around the world. This year, the six Next Generation Leaders come from universities and research institutes in the U.S., Canada and Germany. They will each have a three-year term on the advisory council.

“The Society is proud to present Dr. Herzog and Dr. Peker with this year’s award,” said SfN President Richard Huganir. “Dr. Herzog is a gifted teacher and science communicator who is committed to increasing diversity through mentoring, while Dr. Peker has been instrumental in demonstrating the benefits of international educational experiences and research collaborations.”

Can electricity serve as an alternative electron supplier for bacterial growth? And can we enhance the electron uptake capacity of bacteria?

Living Earth Collaborative grant supports efforts to understand if Peter's Angola colobus monkeys represent one or two subspecies

Joseph Jez began his work with the Biology Department ten years ago as an assistant professor. He is now Professor of Biology, Howard Hughes Medical Institute Professor and as of July 1, 2018 the Biology Department Chair. We sat down to talk about the changes he’s witnessed over the last decade as well as what he would like to see in the future.

A new study in the journal Scientific Reports gets to the bottom of it: Why do dogs that are trained to locate poop sometimes find the wrong kind of poop?

Li also collaborated with Erik Herzog, professor of biology in Arts & Sciences at Washington University who studies the cellular and molecular basis of circadian rhythms in mammals

Improbable Destinies: Fate, Chance and the Future of Evolution

A&S professor awarded $2 million for research that could help defeat antibiotic-resistant infections

A $762k collaborative NSF grant will fund a partnership between Joseph Jez (Wash U Biology chair) with Hiroshi Maeda (U Wisconsin-Madison; Botany) on the mechanisms and impacts of de-regulating aromatic amino acid biosynthesis in plants.

An immediate before-after comparison — the first of its kind — shows that survivors of a hurricane have different traits than the general population.

Joan Strassmann and David Queller were awarded a $1,139,388 National Science Foundation grant for the four-year project "Kith and kin in amoeba-bacteria cooperation", about the evolution of cooperation both within and between species, using an amoeba-bacteria system.

The two year grant was awarded from the National Science Foundation

Next step could be ‘nitrogen-fixing’ plants that can do the same, reducing need for fertilizer.

“We train our students to do any type of science. We want to give them the tools so that whether they go into industry, academia or government, they will benefit from what they learned in graduate school,” said Dixit.

Congratulations to Jonathan Myers and Hani Zaher who both received promotions with tenure and are now Associate Professors of Biology in Arts & Sciences.

Victoria L. May, assistant dean in Arts & Sciences and executive director of the Institute for School Partnership, has been honored for her work with students.

New species are not hidden only in exotic locales. Recently, graduate student Ben Wolf found a new species of alga in Forest Park.

Three scientists at Washington University in St. Louis are among the 84 new members and 21 foreign associates elected May 1 to the National Academy of Sciences (NAS) in recognition of their distinguished and continuing achievements in original research.

Warmer active seasons and fewer freeze-thaw events lead to big changes for the tiniest Arctic ambassadors — its arthropods.

Nowadays Sally Elgin would probably be referred to as gifted or talented. But in the 1950s, a really smart girl was obnoxious or a nerd.

In the midst of what scientists consider to be a sixth mass extinction event, Washington University is joining forces with the Missouri Botanical Garden and the Saint Louis Zoo to collaborate on ­ life-saving research and conservation efforts.

Read about Jonathan's background and his new collaboration with MOBOT and the STL Zoo.

Keith Hengen is wowed by the organizational prowess of our brains. How, he wonders, do hundreds of millions of neurons interact reliably time after time, especially given that the proteins that power neurons have half-lives on the order of seconds to hours?

Forty middle and high school students participated in the most recent Teen Science Café in March 2018.

Yehuda Ben-Shahar, associate professor of biology in Arts & Sciences, has been awarded $770,000 by the National Science Foundation to investigate how insects produce and perceive mating pheromones as species diversify.

Three years after launching the Biotech Explorers Pathway, a unique opportunity for first-year and sophomore students, biology professor Joe Jez shares how the program started and some of what its students have accomplished so far.