This course will cover equilibria, kinetics and mechanisms of macromolecular interactions from a quantitative perspective. Thermodynamics, multiple binding equilibria (binding polynomials), linkage phenomena, cooperativity, allostery, macromolecular assembly, enzyme catalysis and mechanism, steady-state and pre-steady-state kinetics, and isotope effects. Modern methods of computer analysis using non-linear least squares fitting and simulation to analyze binding isotherms and full kinetic time courses is emphasized. Prerequisite, physical chemistry, biochemistry, calculus, and organic chemistry. 3 class hours per week.
Section 01Macromolecular Interactions
INSTRUCTOR: GreenbergView Course Listing