Immunobiology is a continuation of Immunobiology I (Bio 5053) taught by the faculty members of the Immunology Program and consists of two sections. In the first section, selected topics are covered in depth that were introduced in Immunobiology I. These include methods in modern immunology, cytokine signaling, DC subsets, tumor immunology, evolution of the immune response, Fc Receptors, alloreactivity, mucosal immunity, inhibitory receptors, vaccines, lymphoorganogenesis and immunopathogenesis. The second section involves Molecular mechanisms of disease (formerly Bio 5261) and will cover human diseases that appear to have an immunological basis. In addition to lectures and evaluation of recent clinical and relevant basic immunology literature, an emphasis will be placed on direct encounters with patients and pathologic material when feasible, providing students with a human aspect to discussions of immune pathogenesis. Diseases covered will include rheumatoid arthritis, allergy, lupus, multiple sclerosis, diabetes, immunodeficiencies, complement diseases and hemophagocytic lymphohistiocytosis. Prereq: DBBS students and Immunobiology I.