Macromolecular Interactions

BIOLOGY AND BIOMEDICAL SCIENCES 5312

This course will cover equilibria, kinetics and mechanisms of macromolecular interactions from a quantitative perspective. Thermodynamics, multiple binding equilibria (binding polynomials), linkage phenomena, cooperativity, allostery, macromolecular assembly, enzyme catalysis and mechanism, steady-state and pre-steady-state kinetics, and isotope effects. Modern methods of computer analysis using non-linear least squares fitting and simulation to analyze binding isotherms and full kinetic time courses is emphasized. Background in calculus, physical chemistry and biochemistry is encouraged.
Course Attributes:

Section 01

Macromolecular Interactions - 01
INSTRUCTOR: Lohman, Kozlov, Galletto, Galburt, Greenberg, Soranno
View Course Listing - SP2022