Next-Gen Genetics: Merging Genetics with Genomic Insights

Forward genetics is a research approach that starts with identifying phenotypic variation (an observable trait or characteristic) and then works towards discovering the genetic basis responsible for that variation. In the dynamic era of genomics, the field of forward genetics offers a powerful approach to uncovering the genetic basis of phenotypic variation across a wide array of organisms. "Next-Gen Genetics" is a cutting-edge upper-level laboratory course that bridges traditional genetic analysis with modern genomic techniques. The course emphasizes the universality and applicability of forward genetics methods in various research systems including animals, plants, and microbes. In this course we will use plants as a model system to explore forward genetic approaches. Through a blend of engaging lectures, interactive bioinformatics labs, and hands-on greenhouse and wet lab sessions, students will journey from the fundamentals of genetic variation and trait inheritance to the forefront of genomic technology. Using next-generation sequencing (NGS) together with bioinformatics tools, participants will experience the thrill of discovery by identifying new trait loci associated with phenotypic traits in a novel research project. This course is an invitation to explore the genetic complexities of living organisms in the genomic age. Whether you're aiming to revolutionize plant breeding, uncover the genetic underpinnings of disease in humans, or explore the vast diversity of microbial life, "Next-Gen Genetics" offers the tools and insights to propel your scientific journey. By the end of this course, students will have designed and carried out an experiment, phenotyped a segregating population of tomato plants, extracted DNA and sent it to be sequenced. Students will then analyze genomic sequences and perform their own Bulk Segregant Analysis experiment to identify genetic loci associated with chosen phenotypes. Due to high demand for this course, please fill out th
Course Attributes: AS NSM; FA NSM; BU SCI

Next-Gen Genetics: Merging Genetics with Genomic Insights

BIOLOGY AND BIOMEDICAL SCIENCES 4346

Section 01

Section A