Andrés López-Sepulcre is interested in a variety of ecological and evolutionary questions, especially involving the relationship between both disciplines.
Within the framework of eco-evolutionary theory, López-Sepulcre asks questions on topics like: the relationship between adaptation on ecosystem processes (e.g. nutrient cycling), density- and frequency-dependent selection, rapid evolution, or the regulation of populations in space and time. Regardless of the question, he is particularly keen on approaching it through the integration of mathematical models (statistical or theoretical) with long-term data and manipulative experiments. Because of this, he devotes a good part of his research to the development of quantitative methods. Prior to his appointment at Washington University, López-Sepulcre was a researcher at the French National Centre for Scientific Research (CRNS) and the University of Jyväskylä in Finland.